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Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis
A decrease in brain-derived neurotrophic factor (BDNF), a neurotrophin essential for synaptic function, plasticity and neuronal survival, is evident early in the progression of Alzheimer’s disease (AD), being apparent in subjects with mild cognitive impairment or mild AD, and both proBDNF and mature...
Autores principales: | Braschi, Chiara, Capsoni, Simona, Narducci, Roberta, Poli, Andrea, Sansevero, Gabriele, Brandi, Rossella, Maffei, Lamberto, Cattaneo, Antonino, Berardi, Nicoletta |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081712/ https://www.ncbi.nlm.nih.gov/pubmed/32676979 http://dx.doi.org/10.1007/s40520-020-01646-5 |
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