Dimerization of PHGDH via the catalytic unit is essential for its enzymatic function

Human D-3-phosphoglycerate dehydrogenase (PHGDH), a key enzyme in de novo serine biosynthesis, is amplified in various cancers and serves as a potential target for anticancer drug development. To facilitate this process, more information is needed on the basic biochemistry of this enzyme. For exampl...

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Detalles Bibliográficos
Autores principales: Xu, Hanyu, Qing, Xiaoyu, Wang, Qian, Li, Chunmei, Lai, Luhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081924/
https://www.ncbi.nlm.nih.gov/pubmed/33753166
http://dx.doi.org/10.1016/j.jbc.2021.100572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081924/
https://www.ncbi.nlm.nih.gov/pubmed/33753166
http://dx.doi.org/10.1016/j.jbc.2021.100572

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