Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolysaccharidosis type II

Pabinafusp alfa is a fusion protein comprising a humanized anti-human transferrin receptor (TfR) antibody and human iduronate-2-sulfatase. It was developed as a novel modality to target central nervous system-related symptoms observed in patients with mucopolysaccharidosis type II (MPS II, also know...

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Detalles Bibliográficos
Autores principales: Yamamoto, Ryuji, Yoden, Eiji, Tanaka, Noboru, Kinoshita, Masafumi, Imakiire, Atsushi, Hirato, Tohru, Minami, Kohtaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081988/
https://www.ncbi.nlm.nih.gov/pubmed/33981582
http://dx.doi.org/10.1016/j.ymgmr.2021.100758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081988/
https://www.ncbi.nlm.nih.gov/pubmed/33981582
http://dx.doi.org/10.1016/j.ymgmr.2021.100758

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