Cargando…

SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights

OBJECTIVE: Bacterial and viral infectious triggers are linked to spondyloarthritis (SpA) including psoriatic arthritis (PsA) development, likely via dendritic cell activation. We investigated spinal entheseal plasmacytoid dendritic cells (pDCs) toll-like receptor (TLR)-7 and 9 activation and therape...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Qiao, Vadakekolathu, Jayakumar, Watad, Abdulla, Sharif, Kassem, Russell, Tobias, Rowe, Hannah, Khan, Almas, Millner, Peter A., Loughenbury, Peter, Rao, Abhay, Dunsmuir, Robert, Timothy, Jake, Damiani, Giovanni, Pigatto, Paolo D. M., Malagoli, Piergiorgio, Banfi, Giuseppe, El-Sherbiny, Yasser M., Bridgewood, Charlie, McGonagle, Dennis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082065/ https://www.ncbi.nlm.nih.gov/pubmed/33936047 http://dx.doi.org/10.3389/fimmu.2021.635018

Ejemplares similares

Identification of myeloid cells in the human enthesis as the main source of local IL-23 production
por: Bridgewood, Charlie, et al.
Publicado: (2019)

Evidence that tissue resident human enthesis γδT-cells can produce IL-17A independently of IL-23R transcript expression
por: Cuthbert, Richard James, et al.
Publicado: (2019)

IL-17A and TNF Modulate Normal Human Spinal Entheseal Bone and Soft Tissue Mesenchymal Stem Cell Osteogenesis, Adipogenesis, and Stromal Function
por: Russell, Tobias, et al.
Publicado: (2021)

Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression
por: Watad, Abdulla, et al.
Publicado: (2020)

Intestinal and enthesis innate immunity in early axial spondyloarthropathy
por: Sharif, Kassem, et al.
Publicado: (2020)

Corrigendum to: Intestinal and enthesis innate immunity in early axial spondyloarthropathy
por: Sharif, Kassem, et al.
Publicado: (2020)

Cytokine “fine tuning” of enthesis tissue homeostasis as a pointer to spondyloarthritis pathogenesis with a focus on relevant TNF and IL-17 targeted therapies
por: Russell, Tobias, et al.
Publicado: (2021)

Severe COVID-19 as a virus-independent immunothrombotic process – Authors' reply
por: McGonagle, Dennis, et al.
Publicado: (2022)

The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study
por: Adawi, Mohammad, et al.
Publicado: (2019)

Why Inhibition of IL-23 Lacked Efficacy in Ankylosing Spondylitis
por: McGonagle, Dennis, et al.
Publicado: (2021)

A role for neutrophils in early enthesitis in spondyloarthritis
por: Stavre, Zheni, et al.
Publicado: (2022)

Benefits of the use of blood conservation in scoliosis surgery
por: Loughenbury, Peter R, et al.
Publicado: (2016)

The Impact of Ramadan Fasting on the Reduction of PASI Score, in Moderate-To-Severe Psoriatic Patients: A Real-Life Multicenter Study
por: Damiani, Giovanni, et al.
Publicado: (2019)

Sex-Based Medicine Meets Psoriatic Arthritis: Lessons Learned and to Learn
por: Bragazzi, Nicola Luigi, et al.
Publicado: (2022)

The IL-23p19/EBI3 heterodimeric cytokine termed IL-39 remains a theoretical cytokine in man
por: Bridgewood, Charlie, et al.
Publicado: (2019)

The Early Phases of Ankylosing Spondylitis: Emerging Insights From Clinical and Basic Science
por: Watad, Abdulla, et al.
Publicado: (2018)

COVID-19: angiotensin II in development of lung immunothrombosis and vasculitis mimics – Author's reply
por: McGonagle, Dennis, et al.
Publicado: (2021)

COVID-19 vasculitis and novel vasculitis mimics
por: McGonagle, Dennis, et al.
Publicado: (2021)

Characterization of Blood Mucosal‐Associated Invariant T Cells in Patients With Axial Spondyloarthritis and of Resident Mucosal‐Associated Invariant T Cells From the Axial Entheses of Non‐Axial Spondyloarthritis Control Patients
por: Rosine, Nicolas, et al.
Publicado: (2022)

Harnessing Big Data, Smart and Digital Technologies and Artificial Intelligence for Preventing, Early Intercepting, Managing, and Treating Psoriatic Arthritis: Insights From a Systematic Review of the Literature
por: Bragazzi, Nicola Luigi, et al.
Publicado: (2022)

Therapeutic implications of ongoing alveolar viral replication in COVID-19
por: McGonagle, Dennis, et al.
Publicado: (2022)

Immune cartography of macrophage activation syndrome in the COVID-19 era
por: McGonagle, Dennis, et al.
Publicado: (2021)

Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection
por: McGonagle, Dennis, et al.
Publicado: (2021)

Time to move away from an oxygen-centric model of pulmonary infarction? – Authors' reply
por: McGonagle, Dennis, et al.
Publicado: (2021)

A tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19
por: McGonagle, Dennis, et al.
Publicado: (2021)

Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients
por: van den Brandt, Stephanie, et al.
Publicado: (2017)

BSR Spondyloarthritis Course, 27 February 2020. Spondyloarthritis: pathogenesis, diagnosis and management
por: Marzo-Ortega, Helena, et al.
Publicado: (2020)

Re: Patiently waiting for the results of anti-IL 6 therapy in severe COVID-19 infection
por: McGonagle, Dennis, et al.
Publicado: (2020)

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease
por: McGonagle, Dennis, et al.
Publicado: (2020)

Enthesitis: Much More Than Focal Insertion Point Inflammation
por: Watad, Abdulla, et al.
Publicado: (2018)

Understanding flare in axial spondyloarthritis: novel insights from daily self-reported flare experience
por: Barnett, Rosemarie, et al.
Publicado: (2021)

Pulmonary intravascular coagulopathy in COVID-19 pneumonia – Authors' reply
por: McGonagle, Dennis, et al.
Publicado: (2020)

Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia
por: McGonagle, Dennis, et al.
Publicado: (2020)

Increased cardiovascular mortality in African Americans with COVID-19
por: McGonagle, Dennis, et al.
Publicado: (2020)

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies
por: McGonagle, Dennis G, et al.
Publicado: (2019)

Mineral Distributions at the Developing Tendon Enthesis
por: Schwartz, Andrea G., et al.
Publicado: (2012)

COVID-19 Vasculitis and vasculopathy-Distinct immunopathology emerging from the close juxtaposition of Type II Pneumocytes and Pulmonary Endothelial Cells
por: Giryes, Sami, et al.
Publicado: (2022)

The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier
por: Macleod, Tom, et al.
Publicado: (2021)

Immune-Mediated Disease Flares or New-Onset Disease in 27 Subjects Following mRNA/DNA SARS-CoV-2 Vaccination
por: Watad, Abdulla, et al.
Publicado: (2021)

The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis
por: Veale, Douglas J, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f4rlcjkq5gnq38t9q3ofjgum3d