Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

Background: Akebia saponin D (ASD) has a variety of biological activities and great medicinal potential, but its oral bioavailability is so low as to limit its development. Its pharmacokinetic profiles and excretion and metabolism in vivo have not been fully elucidated. This study was an attempt in...

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Detalles Bibliográficos
Autores principales: Li, Pengfei, Peng, Jun, Li, Yuexin, Gong, Lili, Lv, Yali, Liu, He, Zhang, Tianhong, Yang, Song, Liu, Hongchuan, Li, Jinglai, Liu, Lihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082176/
https://www.ncbi.nlm.nih.gov/pubmed/33935711
http://dx.doi.org/10.3389/fphar.2021.621003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082176/
https://www.ncbi.nlm.nih.gov/pubmed/33935711
http://dx.doi.org/10.3389/fphar.2021.621003

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