Vanillin downregulates NNMT and attenuates NNMT-related resistance to 5-fluorouracil via ROS-induced cell apoptosis in colorectal cancer cells

Chemoresistance is the main cause of poor prognosis in colorectal cancer (CRC). Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that is upregulated in various tumor types. It has been reported that NNMT inhibits apoptosis and enhances resistance to 5-fluorouracil (5-Fu) via inhibition...

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Detalles Bibliográficos
Autores principales: Li, Guoli, Kong, Beibei, Tong, Qingchao, Li, Yejia, Chen, Lifen, Zeng, Jin, Yu, Haitao, Xie, Xinyou, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082342/
https://www.ncbi.nlm.nih.gov/pubmed/33907844
http://dx.doi.org/10.3892/or.2021.8061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082342/
https://www.ncbi.nlm.nih.gov/pubmed/33907844
http://dx.doi.org/10.3892/or.2021.8061

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