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Vanillin downregulates NNMT and attenuates NNMT-related resistance to 5-fluorouracil via ROS-induced cell apoptosis in colorectal cancer cells
Chemoresistance is the main cause of poor prognosis in colorectal cancer (CRC). Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that is upregulated in various tumor types. It has been reported that NNMT inhibits apoptosis and enhances resistance to 5-fluorouracil (5-Fu) via inhibition...
Autores principales: | Li, Guoli, Kong, Beibei, Tong, Qingchao, Li, Yejia, Chen, Lifen, Zeng, Jin, Yu, Haitao, Xie, Xinyou, Zhang, Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082342/ https://www.ncbi.nlm.nih.gov/pubmed/33907844 http://dx.doi.org/10.3892/or.2021.8061 |
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