Imaging 6-Phosphogluconolactonase Activity in Brain Tumors In Vivo Using Hyperpolarized δ-[1-(13)C]gluconolactone

INTRODUCTION: The pentose phosphate pathway (PPP) is essential for NADPH generation and redox homeostasis in cancer, including glioblastomas. However, the precise contribution to redox and tumor proliferation of the second PPP enzyme 6-phosphogluconolactonase (PGLS), which converts 6-phospho-δ-gluco...

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Detalles Bibliográficos
Autores principales: Batsios, Georgios, Taglang, Céline, Cao, Peng, Gillespie, Anne Marie, Najac, Chloé, Subramani, Elavarasan, Wilson, David M., Flavell, Robert R., Larson, Peder E. Z., Ronen, Sabrina M., Viswanath, Pavithra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082394/
https://www.ncbi.nlm.nih.gov/pubmed/33937017
http://dx.doi.org/10.3389/fonc.2021.589570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082394/
https://www.ncbi.nlm.nih.gov/pubmed/33937017
http://dx.doi.org/10.3389/fonc.2021.589570

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