CRISPR/dCas9-Mediated Parkin Inhibition Impairs Mitophagy and Aggravates Apoptosis of Rat Nucleus Pulposus Cells Under Oxidative Stress

OBJECTIVE: The aim of this study is to explore the role of Parkin in intervertebral disk degeneration (IDD) and its mitophagy regulation mechanism. STUDY DESIGN AND METHODS: Rat nucleus pulposus (NP) cells were stimulated with hydrogen peroxide (H(2)O(2)) to a mimic pathological condition. Apoptosis...

Descripción completa

Detalles Bibliográficos
Autores principales: Lan, Tao, Zheng, Yu-chen, Li, Ning-dao, Chen, Xiao-sheng, Shen, Zhe, Yan, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082403/
https://www.ncbi.nlm.nih.gov/pubmed/33937342
http://dx.doi.org/10.3389/fmolb.2021.674632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082403/
https://www.ncbi.nlm.nih.gov/pubmed/33937342
http://dx.doi.org/10.3389/fmolb.2021.674632

Ejemplares similares