PseudotimeDE: inference of differential gene expression along cell pseudotime with well-calibrated p-values from single-cell RNA sequencing data

To investigate molecular mechanisms underlying cell state changes, a crucial analysis is to identify differentially expressed (DE) genes along the pseudotime inferred from single-cell RNA-sequencing data. However, existing methods do not account for pseudotime inference uncertainty, and they have ei...

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Detalles Bibliográficos
Autores principales: Song, Dongyuan, Li, Jingyi Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082818/
https://www.ncbi.nlm.nih.gov/pubmed/33926517
http://dx.doi.org/10.1186/s13059-021-02341-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082818/
https://www.ncbi.nlm.nih.gov/pubmed/33926517
http://dx.doi.org/10.1186/s13059-021-02341-y

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