Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity

Human apurinic/apyrimidinic endonuclease 1 (APE1) participates in the DNA repair system. It is believed that the main biological function of APE1 is Mg(2+)-dependent hydrolysis of AP-sites in DNA. On the base of structural data, kinetic studies, and mutation analysis, the key stages of APE1 interact...

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Detalles Bibliográficos
Autores principales: Kuznetsova, A. A., Gavrilova, A. A., Novopashina, D. S., Fedorova, O. S., Kuznetsov, N. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Enzymology of DNA Repair Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083922/
https://www.ncbi.nlm.nih.gov/pubmed/33948042
http://dx.doi.org/10.1134/S0026893321020102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083922/
https://www.ncbi.nlm.nih.gov/pubmed/33948042
http://dx.doi.org/10.1134/S0026893321020102

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