Cargando…

Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity

Human apurinic/apyrimidinic endonuclease 1 (APE1) participates in the DNA repair system. It is believed that the main biological function of APE1 is Mg(2+)-dependent hydrolysis of AP-sites in DNA. On the base of structural data, kinetic studies, and mutation analysis, the key stages of APE1 interact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuznetsova, A. A., Gavrilova, A. A., Novopashina, D. S., Fedorova, O. S., Kuznetsov, N. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pleiades Publishing 2021
Materias:	Enzymology of DNA Repair Systems
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083922/ https://www.ncbi.nlm.nih.gov/pubmed/33948042 http://dx.doi.org/10.1134/S0026893321020102

Ejemplares similares

Effect of the Substrate Structure and Metal Ions on the Hydrolysis of Undamaged RNA by Human AP Endonuclease APE1
por: Kuznetsova, A. A., et al.
Publicado: (2020)

Comparative Analysis of Exo- and Endonuclease Activities of APE1-like Enzymes
por: Davletgildeeva, Anastasiia T., et al.
Publicado: (2022)

Kinetic Features of 3′-5′ Exonuclease Activity of Human AP-Endonuclease APE1
por: Kuznetsova, Alexandra A., et al.
Publicado: (2018)

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex
por: Jin, Zhinan, et al.
Publicado: (2012)

DNA damage recognition /
Publicado: (2006)

SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
por: Dai, Han, et al.
Publicado: (2010)

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor
por: Tarhonskaya, Hanna, et al.
Publicado: (2015)

The Superfast Human Extraocular Myosin Is Kinetically Distinct from the Fast Skeletal IIa, IIb, and IId Isoforms
por: Bloemink, Marieke J., et al.
Publicado: (2013)

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY
por: Jin, Zhinan, et al.
Publicado: (2011)

The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors
por: White, Mark D., et al.
Publicado: (2018)

Dissecting the Catalytic Mechanism of Trypanosoma brucei Trypanothione Synthetase by Kinetic Analysis and Computational Modeling
por: Leroux, Alejandro E., et al.
Publicado: (2013)

The Thermodynamic Basis for Viral RNA Detection by the RIG-I Innate Immune Sensor
por: Vela, Adriana, et al.
Publicado: (2012)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
por: Waz, Shaimaa, et al.
Publicado: (2017)

Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1
por: Paumann-Page, Martina, et al.
Publicado: (2017)

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression
por: Fisher, Nicholas, et al.
Publicado: (2012)

Kinetic Characterization of Single Strand Break Ligation in Duplex DNA by T4 DNA Ligase
por: Lohman, Gregory J. S., et al.
Publicado: (2011)

Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms
por: Heissler, Sarah M., et al.
Publicado: (2011)

Coupled chemistry kinetics demonstrate the utility of functionalized Sup35 amyloid nanofibrils in biocatalytic cascades
por: Schmuck, Benjamin, et al.
Publicado: (2019)

Pre-steady-state Kinetic Analysis of a Family D DNA Polymerase from Thermococcus sp. 9°N Reveals Mechanisms for Archaeal Genomic Replication and Maintenance
por: Schermerhorn, Kelly M., et al.
Publicado: (2015)

Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
por: Brewitz, Lennart, et al.
Publicado: (2020)

Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
por: Söderholm, Annika, et al.
Publicado: (2020)

Demonstration of Lignin-to-Peroxidase Direct Electron Transfer: A TRANSIENT-STATE KINETICS, DIRECTED MUTAGENESIS, EPR, AND NMR STUDY
por: Sáez-Jiménez, Verónica, et al.
Publicado: (2015)

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates
por: Egger, Sigrid, et al.
Publicado: (2012)

Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity
por: Elnatan, Daniel, et al.
Publicado: (2018)

Nitro-fatty acids as activators of hSIRT6 deacetylase activity
por: Carreño, Mara, et al.
Publicado: (2021)

Interactions Outside the Proteinase-binding Loop Contribute Significantly to the Inhibition of Activated Coagulation Factor XII by Its Canonical Inhibitor from Corn
por: Korneeva, Vera A., et al.
Publicado: (2014)

Zymogen and activated protein C have similar structural architecture
por: Stojanovski, Bosko M., et al.
Publicado: (2020)

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog
por: Nguyen, Suong, et al.
Publicado: (2013)

Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling
por: Ukpabi, Georgia, et al.
Publicado: (2012)

Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation
por: Santamaria, Salvatore, et al.
Publicado: (2017)

GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone–rod dystrophy but not for stationary night blindness
por: Peshenko, Igor V., et al.
Publicado: (2021)

Origin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase: EFFECT OF THE BASICITY OF AN ACTIVE SITE HIS RESIDUE
por: Hernandez-Ortega, Aitor, et al.
Publicado: (2014)

Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody
por: Kenniston, Jon A., et al.
Publicado: (2014)

Structure and Activity of Paenibacillus polymyxa Xyloglucanase from Glycoside Hydrolase Family 44
por: Ariza, Antonio, et al.
Publicado: (2011)

Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia
por: Dong, Qian, et al.
Publicado: (2015)

Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis
por: Seeliger, Jessica C., et al.
Publicado: (2012)

The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN
por: Day, Martin A., et al.
Publicado: (2021)

Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and S(N)1 chemotherapeutic agents
por: Armijo, Amanda L, et al.
Publicado: (2023)

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities
por: Mattoo, Seema, et al.
Publicado: (2011)

Defining the mutation signatures of DNA polymerase θ in cancer genomes
por: Hwang, Taejoo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k3ndgd1clrldqu8aar3ac8todl