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Systematic comparison and prediction of the effects of missense mutations on protein-DNA and protein-RNA interactions

The binding affinities of protein-nucleic acid interactions could be altered due to missense mutations occurring in DNA- or RNA-binding proteins, therefore resulting in various diseases. Unfortunately, a systematic comparison and prediction of the effects of mutations on protein-DNA and protein-RNA...

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Detalles Bibliográficos
Autores principales: Jiang, Yao, Liu, Hui-Fang, Liu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084330/
https://www.ncbi.nlm.nih.gov/pubmed/33872313
http://dx.doi.org/10.1371/journal.pcbi.1008951