MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity

Expression quantitative trait loci (eQTL) studies are used to understand the regulatory function of non-coding genome-wide association study (GWAS) risk loci, but colocalization alone does not demonstrate a causal relationship of gene expression affecting a trait. Evidence for mediation, that pertur...

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Detalles Bibliográficos
Autores principales: Zhu, Anqi, Matoba, Nana, Wilson, Emma P., Tapia, Amanda L., Li, Yun, Ibrahim, Joseph G., Stein, Jason L., Love, Michael I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084342/
https://www.ncbi.nlm.nih.gov/pubmed/33872308
http://dx.doi.org/10.1371/journal.pgen.1009455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084342/
https://www.ncbi.nlm.nih.gov/pubmed/33872308
http://dx.doi.org/10.1371/journal.pgen.1009455

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