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MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity

Expression quantitative trait loci (eQTL) studies are used to understand the regulatory function of non-coding genome-wide association study (GWAS) risk loci, but colocalization alone does not demonstrate a causal relationship of gene expression affecting a trait. Evidence for mediation, that pertur...

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Detalles Bibliográficos
Autores principales:	Zhu, Anqi, Matoba, Nana, Wilson, Emma P., Tapia, Amanda L., Li, Yun, Ibrahim, Joseph G., Stein, Jason L., Love, Michael I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084342/ https://www.ncbi.nlm.nih.gov/pubmed/33872308 http://dx.doi.org/10.1371/journal.pgen.1009455

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