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Balancing the influenza neuraminidase and hemagglutinin responses by exchanging the vaccine virus backbone

Virions are a common antigen source for many viral vaccines. One limitation to using virions is that the antigen abundance is determined by the content of each protein in the virus. This caveat especially applies to viral-based influenza vaccines where the low abundance of the neuraminidase (NA) sur...

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Detalles Bibliográficos
Autores principales: Gao, Jin, Wan, Hongquan, Li, Xing, Rakic Martinez, Mira, Klenow, Laura, Gao, Yamei, Ye, Zhiping, Daniels, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084346/
https://www.ncbi.nlm.nih.gov/pubmed/33872324
http://dx.doi.org/10.1371/journal.ppat.1009171