Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA

The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that this SNP is involved in the migration and hyperactivation of Rac1 in dendritic cells. Mucosal healing, currently the main target for inflam...

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Detalles Bibliográficos
Autores principales: Prins, Marileen M. C., Giugliano, Francesca P., van Roest, Manon, van de Graaf, Stan F. J., Koelink, Pim J., Wildenberg, Manon E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084572/
https://www.ncbi.nlm.nih.gov/pubmed/33973626
http://dx.doi.org/10.1242/dmm.047233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084572/
https://www.ncbi.nlm.nih.gov/pubmed/33973626
http://dx.doi.org/10.1242/dmm.047233

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