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Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA
The ATG16L1 T300A single-nucleotide polymorphism (SNP) is associated with Crohn's disease and causes an autophagy impairment. We have previously shown that this SNP is involved in the migration and hyperactivation of Rac1 in dendritic cells. Mucosal healing, currently the main target for inflam...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084572/ https://www.ncbi.nlm.nih.gov/pubmed/33973626 http://dx.doi.org/10.1242/dmm.047233 |