Screening for inhibitory effects of crude drugs on furin-like enzymatic activities

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains a cleavage motif R-X-X-R for furin-like enzymes at the boundary of the S1/S2 subunits. The cleavage of the site by cellular proteases is essential for S protein activation and virus entry. We screened the...

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Detalles Bibliográficos
Autores principales: Kiba, Yuka, Oyama, Rio, Misawa, Sae, Tanikawa, Takashi, Kitamura, Masashi, Suzuki, Ryuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Natural Resource Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084592/
https://www.ncbi.nlm.nih.gov/pubmed/33928494
http://dx.doi.org/10.1007/s11418-021-01519-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084592/
https://www.ncbi.nlm.nih.gov/pubmed/33928494
http://dx.doi.org/10.1007/s11418-021-01519-9

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