Uncoupling Protein 2 Deficiency Enhances NLRP3 Inflammasome Activation Following Hyperglycemia-Induced Exacerbation of Cerebral Ischemia and Reperfusion Damage In Vitro and In Vivo

Mitochondrial uncoupling protein 2 (UCP2) deficiency exacerbates brain damage following cerebral ischemia/reperfusion (I/R). The Nod-like receptor protein-3 (NLRP3) inflammasome also plays a vital role in cerebral I/R damage. However, the effect of UCP2 on NLRP3 inflammasome-mediated hyperglycemia a...

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Detalles Bibliográficos
Autores principales: Zhang, Ting, He, Mao-Tao, Zhang, Xiao-Peng, Jing, Li, Zhang, Jian-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084809/
https://www.ncbi.nlm.nih.gov/pubmed/33735403
http://dx.doi.org/10.1007/s11064-021-03270-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084809/
https://www.ncbi.nlm.nih.gov/pubmed/33735403
http://dx.doi.org/10.1007/s11064-021-03270-9

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