Inducible knockout of Clec16a in mice results in sensory neurodegeneration

CLEC16A has been shown to play a role in autophagy/mitophagy processes. Additionally, genetic variants in CLEC16A have been implicated in multiple autoimmune diseases. We generated an inducible whole-body knockout, Clec16a(ΔUBC) mice, to investigate the loss of function of CLEC16A. The mice exhibite...

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Detalles Bibliográficos
Autores principales: Hain, Heather S., Pandey, Rahul, Bakay, Marina, Strenkowski, Bryan P., Harrington, Danielle, Romer, Micah, Motley, William W., Li, Jian, Lancaster, Eunjoo, Roth, Lindsay, Grinspan, Judith B., Scherer, Steven S., Hakonarson, Hakon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084945/
https://www.ncbi.nlm.nih.gov/pubmed/33927318
http://dx.doi.org/10.1038/s41598-021-88895-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084945/
https://www.ncbi.nlm.nih.gov/pubmed/33927318
http://dx.doi.org/10.1038/s41598-021-88895-0

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