Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network

GPCR-regulated cAMP production from endosomes can specify signaling to the nucleus by moving the source of cAMP without changing its amount. How this is possible remains unknown because cAMP gradients dissipate over the nanoscale whereas endosomes typically localize microns from the nucleus. We show...

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Detalles Bibliográficos
Autores principales: Peng, Grace E., Pessino, Veronica, Huang, Bo, von Zastrow, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084946/
https://www.ncbi.nlm.nih.gov/pubmed/33649598
http://dx.doi.org/10.1038/s41589-021-00747-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084946/
https://www.ncbi.nlm.nih.gov/pubmed/33649598
http://dx.doi.org/10.1038/s41589-021-00747-0

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