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Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network
GPCR-regulated cAMP production from endosomes can specify signaling to the nucleus by moving the source of cAMP without changing its amount. How this is possible remains unknown because cAMP gradients dissipate over the nanoscale whereas endosomes typically localize microns from the nucleus. We show...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084946/ https://www.ncbi.nlm.nih.gov/pubmed/33649598 http://dx.doi.org/10.1038/s41589-021-00747-0 |