Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase

O-GlcNAc is an essential and dynamic post-translational modification presented on thousands of nucleocytoplasmic proteins. Interrogating the role of O-GlcNAc on a single target protein is crucial yet challenging to perform in cells. Herein, we developed a nanobody-fused split O-GlcNAcase (OGA) as an...

Descripción completa

Detalles Bibliográficos
Autores principales: Ge, Yun, Ramirez, Daniel H., Yang, Bo, D’Souza, Alexandria K., Aonbangkhen, Chanat, Wong, Stephanie, Woo, Christina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085020/
https://www.ncbi.nlm.nih.gov/pubmed/33686291
http://dx.doi.org/10.1038/s41589-021-00757-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085020/
https://www.ncbi.nlm.nih.gov/pubmed/33686291
http://dx.doi.org/10.1038/s41589-021-00757-y

Ejemplares similares