Allostery of atypical modulators at oligomeric G protein-coupled receptors

Many G protein-coupled receptors (GPCRs) are therapeutic targets, with most drugs acting at the orthosteric site. Some GPCRs also possess allosteric sites, which have become a focus of drug discovery. In the M(2) muscarinic receptor, allosteric modulators regulate the binding and functional effects...

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Detalles Bibliográficos
Autores principales: Shivnaraine, Rabindra V., Kelly, Brendan, Elmslie, Gwendolynne, Huang, Xi-Ping, Dong, Yue John, Seidenberg, Margaret, Wells, James W., Ellis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085029/
https://www.ncbi.nlm.nih.gov/pubmed/33927236
http://dx.doi.org/10.1038/s41598-021-88399-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085029/
https://www.ncbi.nlm.nih.gov/pubmed/33927236
http://dx.doi.org/10.1038/s41598-021-88399-x

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