TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable TRPM2 ion channels and generating an intracell...

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Detalles Bibliográficos
Autores principales: Morad, Hassan, Luqman, Suaib, Tan, Chun-Hsiang, Swann, Victoria, McNaughton, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085234/
https://www.ncbi.nlm.nih.gov/pubmed/33927223
http://dx.doi.org/10.1038/s41598-021-88224-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085234/
https://www.ncbi.nlm.nih.gov/pubmed/33927223
http://dx.doi.org/10.1038/s41598-021-88224-5

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