How to assess the structural dynamics of transcription factors by integrating sparse NMR and EPR constraints with molecular dynamics simulations

We review recent advances in modeling structural ensembles of transcription factors from nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopic data, integrated with molecular dynamics (MD) simulations. We focus on approaches that confirm computed conformational ens...

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Detalles Bibliográficos
Autores principales: Kozak, Fanny, Kurzbach, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085671/
https://www.ncbi.nlm.nih.gov/pubmed/33995905
http://dx.doi.org/10.1016/j.csbj.2021.04.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085671/
https://www.ncbi.nlm.nih.gov/pubmed/33995905
http://dx.doi.org/10.1016/j.csbj.2021.04.020

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