Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys

Defects in endothelial cells cause deterioration in kidney function and structure. Here, we found that endothelial SIRT3 regulates metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice. By analyzing, gain of function of the SIRT3 gene by overexpression in a fibrotic mouse strain c...

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Detalles Bibliográficos
Autores principales: Srivastava, Swayam Prakash, Li, Jinpeng, Takagaki, Yuta, Kitada, Munehiro, Goodwin, Julie E., Kanasaki, Keizo, Koya, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086030/
https://www.ncbi.nlm.nih.gov/pubmed/33981977
http://dx.doi.org/10.1016/j.isci.2021.102390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086030/
https://www.ncbi.nlm.nih.gov/pubmed/33981977
http://dx.doi.org/10.1016/j.isci.2021.102390

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