Cargando…

A novel peptide antagonist of the human growth hormone receptor

Excess circulating human growth hormone (hGH) in vivo is linked to metabolic and growth disorders such as cancer, diabetes, and acromegaly. Consequently, there is considerable interest in developing antagonists of hGH action. Here, we present the design, synthesis, and characterization of a 16-resid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Basu, Reetobrata, Nahar, Khairun, Kulkarni, Prateek, Kerekes, Olivia, Sattler, Maya, Hall, Zachary, Neggers, Sebastian, Holub, Justin M., Kopchick, John J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086144/ https://www.ncbi.nlm.nih.gov/pubmed/33774052 http://dx.doi.org/10.1016/j.jbc.2021.100588

Ejemplares similares

A Novel Peptide Antagonist of the Human Growth Hormone Receptor
por: Basu, Reetobrata None, et al.
Publicado: (2021)

Structure and function of a dual antagonist of the human growth hormone and prolactin receptors with site-specific PEG conjugates
por: Basu, Reetobrata, et al.
Publicado: (2023)

Effects of Growth Hormone on Pancreatic Cancer Derived Exosomes
por: Kulkarni, Prateek, et al.
Publicado: (2021)

SAT-LB053 Investigating the Effects of Growth Hormone on Tumor-derived Exosome Output and Content
por: Kulkarni, Prateek, et al.
Publicado: (2019)

OR0304 Novel Dual Antagonists Of The Growth Hormone Receptor And The Prolactin Receptor
por: Basu, Reetobrata, et al.
Publicado: (2023)

THU549 Targeting The Growth Hormone Receptor Attenuates Tumor Exosome Mediated Propagation Of Chemoresistance In Melanoma
por: Kulkarni, Prateek, et al.
Publicado: (2023)

Growth Hormone Receptor Inhibition Sensitizes Human Pancreatic Cancer to Chemotherapy Treatments
por: Basu, Reetobrata, et al.
Publicado: (2021)

THU545 Growth Hormone Receptor Antagonist As A Novel Combination Therapy Against Triple Negative Breast Cancer
por: Mora-Criollo, Patricia, et al.
Publicado: (2023)

OR05-04 Growth Hormone Receptor Antagonism Markedly Improves Therapeutic Response In Mouse Models Of Melanoma, Liver Cancer, Pancreatic Cancer And Cholangiocarcinoma
por: Basu, Reetobrata, et al.
Publicado: (2023)

The effects of growth hormone on therapy resistance in cancer
por: Basu, Reetobrata, et al.
Publicado: (2019)

Effects of Growth Hormone in Human Melanoma Drug Resistance
por: Arora, Pranay, et al.
Publicado: (2021)

Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways
por: Basu, Reetobrata, et al.
Publicado: (2017)

SUN-336 Autocrine / Paracrine Growth Hormone (GH) Drives Multimodal Therapy Resistance in Growth Hormone Receptor (GHR)-expressing Human Cancers
por: Basu, Reetobrata, et al.
Publicado: (2019)

SAT-181 Characterization of Adult Growth Hormone Receptor Gene-Disrupted Mice
por: Duran-Ortiz, Silvana, et al.
Publicado: (2019)

Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan
por: Duran‐Ortiz, Silvana, et al.
Publicado: (2021)

Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo
por: Basu, Reetobrata, et al.
Publicado: (2022)

Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo
por: Qian, Yanrong, et al.
Publicado: (2020)

Differential inhibition of postnatal brain, spinal cord and body growth by a growth hormone antagonist
por: McIlwain, DL, et al.
Publicado: (2004)

Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma
por: Basu, Reetobrata, et al.
Publicado: (2019)

Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist
por: Pollak, M, et al.
Publicado: (2001)

High growth hormone serum partially protects mice against Trypanosoma cruzi infection
por: Mora‐Criollo, Patricia, et al.
Publicado: (2023)

SAT-LB054 Growth Hormone Receptor (GHR) Antagonism Suppresses Hepatocellular Carcinoma Growth in a Syngeneic Mouse Model
por: Mathes, Samuel, et al.
Publicado: (2019)

New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
por: List, Edward O., et al.
Publicado: (2019)

Growth Hormone Receptor Gene Disruption in Mature-Adult Mice Improves Glucose Metabolism and Lifespan in Females
por: Duran-Ortiz, Silvana, et al.
Publicado: (2021)

MON-476 Growth Hormone and the Glomerular Podocyte: Studies of Podocyte-Specific Growth Hormone Receptor Gene Deletion in Mice
por: Brittain, Alison, et al.
Publicado: (2019)

Structural Motif Descriptors as a Way To Elucidate the Agonistic or Antagonistic Activity of Growth Hormone–Releasing Hormone Peptide Analogues
por: Jeanne Dit Fouque, Kevin, et al.
Publicado: (2018)

Screening and identification of a non-peptide antagonist for the peptide hormone receptor in Arabidopsis
por: Shinohara, Hidefumi, et al.
Publicado: (2019)

Growth Hormone Resistance—Special Focus on Inflammatory Bowel Disease
por: Soendergaard, Christoffer, et al.
Publicado: (2017)

The Effect of the GH/IGF-1 Axis During Trypanosoma Cruzi Infection
por: Mora-Criollo, Patricia, et al.
Publicado: (2021)

Effects of Growth Hormone Receptor Ablation in Corticotropin-Releasing Hormone Cells
por: dos Santos, Willian O., et al.
Publicado: (2021)

MON-479 Gross and Microscopic Intestinal Morphology of Bovine Growth Hormone Transgenic Mice Longitudinally
por: Young, Jonathan, et al.
Publicado: (2019)

Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma
por: Villanova, Tania, et al.
Publicado: (2019)

The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies
por: Duran-Ortiz, Silvana, et al.
Publicado: (2017)

SAT-603 Growth Hormone-Releasing Hormone (GHRH) Antagonists Stimulate Feeding in Mice
por: Leone, Sheila, et al.
Publicado: (2020)

SAT033 Disruption Of GHR In “Middle Aged” Mice Enhances Insulin Sensitivity And Extends Male Lifespan
por: Duran-Ortiz, Silvana, et al.
Publicado: (2023)

Characterization of Growth Hormone Resistance in Experimental and Ulcerative Colitis
por: Soendergaard, Christoffer, et al.
Publicado: (2017)

Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice
por: Peroni, Cibele N., et al.
Publicado: (2012)

Inhibition of in vivo proliferation of androgen-independent prostate cancers by an antagonist of growth hormone-releasing hormone.
por: Jungwirth, A., et al.
Publicado: (1997)

Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs
por: Akhter, Mohammad S., et al.
Publicado: (2020)

Growth Hormone-Releasing Hormone Receptor Antagonist Modulates Lung Inflammation and Fibrosis due to Bleomycin
por: Zhang, Chongxu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1ncgq1bc4rhpa81sq0vjr6t7pj