Cargando…
Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling
Notch receptors maintain skeletal homeostasis. NOTCH1 and 2 have been studied for their effects on bone remodeling. Although NOTCH3 plays a significant role in vascular physiology, knowledge about its function in other cellular environments, including bone, is limited. The present study was conducte...
Autores principales: | Canalis, Ernesto, Zanotti, Stefano, Schilling, Lauren, Eller, Tabitha, Yu, Jungeun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086145/ https://www.ncbi.nlm.nih.gov/pubmed/33774049 http://dx.doi.org/10.1016/j.jbc.2021.100583 |
Ejemplares similares
-
Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function
por: Yu, Jungeun, et al.
Publicado: (2021) -
Use of antisense oligonucleotides to target Notch3 in skeletal cells
por: Canalis, Ernesto, et al.
Publicado: (2022) -
NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α
por: Canalis, Ernesto, et al.
Publicado: (2023) -
Sex and Genetic Factors Determine Osteoblastic Differentiation Potential of Murine Bone Marrow Stromal Cells
por: Zanotti, Stefano, et al.
Publicado: (2014) -
Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone
por: Xiong, Jinhu, et al.
Publicado: (2015)