Cargando…

Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis

Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation and is abnormally elevated in varied kidney diseases offers a novel target for the treatment of renal inflammation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Simeng, Huang, Zhimin, Tang, Anna, Wu, Xiaoqing, Aube, Jeffrey, Xu, Liang, Xing, Changying, Huang, Yufeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086301/ https://www.ncbi.nlm.nih.gov/pubmed/32478392 http://dx.doi.org/10.1042/CS20200193

Ejemplares similares

Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosis
por: Huang, Zhimin, et al.
Publicado: (2023)

Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence
por: Yi, Jie, et al.
Publicado: (2010)

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
por: Kaur, Kawaljit, et al.
Publicado: (2017)

Functional inhibition of the RNA‐binding protein HuR sensitizes triple‐negative breast cancer to chemotherapy
por: Wei, Lanjing, et al.
Publicado: (2023)

The RNA-Binding Protein HuR in Digestive System Tumors
por: Song, Xiaoqing, et al.
Publicado: (2020)

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2019)

MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats
por: Ferrigno, Andrea, et al.
Publicado: (2023)

Correction: Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2023)

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
por: Andrade, Daniel, et al.
Publicado: (2019)

Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
por: Wu, Xiaoqing, et al.
Publicado: (2020)

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs
por: Yoon, Je-Hyun, et al.
Publicado: (2014)

The RNA-binding protein HuR is a negative regulator in adipogenesis
por: Siang, Diana Teh Chee, et al.
Publicado: (2020)

The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells
por: Allegri, Lorenzo, et al.
Publicado: (2019)

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
por: Muralidharan, Ranganayaki, et al.
Publicado: (2017)

Post-transcriptional regulation of Pabpn1 by the RNA binding protein HuR
por: Phillips, Brittany L, et al.
Publicado: (2018)

The RNA-binding protein HuR is required for maintenance of the germinal centre response
por: Osma-Garcia, Ines C., et al.
Publicado: (2021)

Low Molecular Weight Inhibitors Targeting the RNA-Binding Protein HuR
por: Joseph, Benjamin Philipp, et al.
Publicado: (2023)

Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
por: Lachiondo-Ortega, Sofia, et al.
Publicado: (2022)

HuB and HuD repress telomerase activity by dissociating HuR from TERC
por: Cheng, Xiaolei, et al.
Publicado: (2021)

Regulation of HuR by DNA Damage Response Kinases
por: Kim, Hyeon Ho, et al.
Publicado: (2010)

Regulation of HuR structure and function by dihydrotanshinone-I
por: Lal, Preet, et al.
Publicado: (2017)

Loss of CARM1 is linked to reduced HuR function in replicative senescence
por: Pang, Lijun, et al.
Publicado: (2013)

Regulation of AT1R expression through HuR by insulin
por: Paukku, Kirsi, et al.
Publicado: (2012)

MiR-200c and HuR in ovarian cancer
por: Prislei, Silvia, et al.
Publicado: (2013)

HuR regulates telomerase activity through TERC methylation
por: Tang, Hao, et al.
Publicado: (2018)

Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression
por: Chen, Jing, et al.
Publicado: (2017)

Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation
por: Christodoulou-Vafeiadou, Eleni, et al.
Publicado: (2018)

The Role of RNA-Binding Protein HuR in Lung Cancer by RNA Sequencing Analysis
por: Ye, Xiong, et al.
Publicado: (2022)

HuR binding to AU-rich elements present in the 3' untranslated region of Classical swine fever virus
por: Nadar, Muthukumar, et al.
Publicado: (2011)

Targeting the RNA-Binding Protein HuR Alleviates Neuroinflammation in Experimental Autoimmune Encephalomyelitis: Potential Therapy for Multiple Sclerosis
por: Borgonetti, Vittoria, et al.
Publicado: (2020)

Glycyrrhetinic Acid Maintains Intestinal Homeostasis via HuR
por: Chen, Gang, et al.
Publicado: (2019)

HuR modulation counteracts lipopolysaccharide response in murine macrophages
por: Bonomo, Isabelle, et al.
Publicado: (2023)

Niclosamide improves cancer immunotherapy by modulating RNA-binding protein HuR-mediated PD-L1 signaling
por: Zhang, Qi, et al.
Publicado: (2023)

Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis
por: Wang, Jun, et al.
Publicado: (2013)

The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response
por: Diaz-Muñoz, Manuel D., et al.
Publicado: (2015)

LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR
por: Kim, Jiyoung, et al.
Publicado: (2016)

Discriminating between HuR and TTP binding sites using the k-spectrum kernel method
por: Bhandare, Shweta, et al.
Publicado: (2017)

A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients
por: Khalaj, Kasra, et al.
Publicado: (2017)

S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD
por: Guo, Tao, et al.
Publicado: (2021)

Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells
por: Jimbo, Masaya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_h249ftta4han5200abu0dcdq7p