Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis

In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the autophagy block induced by Mycobacterium tuberculosis (Mtb) and promotes a Th1 response via IL-12 secretion. Here, the immunostimulatory activity of rapamycin in Mtb-infected DC was fur...

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Detalles Bibliográficos
Autores principales: Etna, Marilena P., Severa, Martina, Licursi, Valerio, Pardini, Manuela, Cruciani, Melania, Rizzo, Fabiana, Giacomini, Elena, Macchia, Gianfranco, Palumbo, Orazio, Stallone, Raffaella, Carella, Massimo, Livingstone, Mark, Negri, Rodolfo, Pellegrini, Sandra, Coccia, Eliana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086600/
https://www.ncbi.nlm.nih.gov/pubmed/33936070
http://dx.doi.org/10.3389/fimmu.2021.649475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086600/
https://www.ncbi.nlm.nih.gov/pubmed/33936070
http://dx.doi.org/10.3389/fimmu.2021.649475

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