eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

BACKGROUND: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. METHODS: Oxygen-induced retinopathy was used as a model...

Descripción completa

Detalles Bibliográficos
Autores principales: Ninchoji, Takeshi, Love, Dominic T, Smith, Ross O, Hedlund, Marie, Vestweber, Dietmar, Sessa, William C, Claesson-Welsh, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087444/
https://www.ncbi.nlm.nih.gov/pubmed/33908348
http://dx.doi.org/10.7554/eLife.64944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087444/
https://www.ncbi.nlm.nih.gov/pubmed/33908348
http://dx.doi.org/10.7554/eLife.64944

Ejemplares similares