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eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

BACKGROUND: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. METHODS: Oxygen-induced retinopathy was used as a model...

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Detalles Bibliográficos
Autores principales:	Ninchoji, Takeshi, Love, Dominic T, Smith, Ross O, Hedlund, Marie, Vestweber, Dietmar, Sessa, William C, Claesson-Welsh, Lena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087444/ https://www.ncbi.nlm.nih.gov/pubmed/33908348 http://dx.doi.org/10.7554/eLife.64944

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