The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

Aggregation of Cu–Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in membrane environment are not correlated with disease pathophysi...

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Detalles Bibliográficos
Autores principales: Sannigrahi, Achinta, Chowdhury, Sourav, Das, Bidisha, Banerjee, Amrita, Halder, Animesh, Kumar, Amaresh, Saleem, Mohammed, Naganathan, Athi N, Karmakar, Sanat, Chattopadhyay, Krishnananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087447/
https://www.ncbi.nlm.nih.gov/pubmed/33825682
http://dx.doi.org/10.7554/eLife.61453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087447/
https://www.ncbi.nlm.nih.gov/pubmed/33825682
http://dx.doi.org/10.7554/eLife.61453

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