Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

An innovative approach to eliminate HIV-1-infected cells emerging out of latency, the major hurdle to HIV-1 cure, is to pharmacologically reactivate viral expression and concomitantly trigger intracellular pro-apoptotic pathways in order to selectively induce cell death (ICD) of infected cells, with...

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Detalles Bibliográficos
Autores principales: Rao, Shringar, Lungu, Cynthia, Crespo, Raquel, Steijaert, Thijs H., Gorska, Alicja, Palstra, Robert-Jan, Prins, Henrieke A. B., van Ijcken, Wilfred, Mueller, Yvonne M., van Kampen, Jeroen J. A., Verbon, Annelies, Katsikis, Peter D., Boucher, Charles A. B., Rokx, Casper, Gruters, Rob A., Mahmoudi, Tokameh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087668/
https://www.ncbi.nlm.nih.gov/pubmed/33931637
http://dx.doi.org/10.1038/s41467-021-22608-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087668/
https://www.ncbi.nlm.nih.gov/pubmed/33931637
http://dx.doi.org/10.1038/s41467-021-22608-z

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