Cargando…

Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

An innovative approach to eliminate HIV-1-infected cells emerging out of latency, the major hurdle to HIV-1 cure, is to pharmacologically reactivate viral expression and concomitantly trigger intracellular pro-apoptotic pathways in order to selectively induce cell death (ICD) of infected cells, with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rao, Shringar, Lungu, Cynthia, Crespo, Raquel, Steijaert, Thijs H., Gorska, Alicja, Palstra, Robert-Jan, Prins, Henrieke A. B., van Ijcken, Wilfred, Mueller, Yvonne M., van Kampen, Jeroen J. A., Verbon, Annelies, Katsikis, Peter D., Boucher, Charles A. B., Rokx, Casper, Gruters, Rob A., Mahmoudi, Tokameh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087668/ https://www.ncbi.nlm.nih.gov/pubmed/33931637 http://dx.doi.org/10.1038/s41467-021-22608-z

Ejemplares similares

Inter-Laboratory Reproducibility of Inducible HIV-1 Reservoir Quantification by TILDA
por: Lungu, Cynthia, et al.
Publicado: (2020)

Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal
por: Stoszko, Mateusz, et al.
Publicado: (2015)

Cohort profile: the Netherlands Cohort Study on Acute HIV infection (NOVA), a prospective cohort study of people with acute or early HIV infection who immediately initiate HIV treatment
por: Dijkstra, Maartje, et al.
Publicado: (2021)

The efficacy and tolerability of latency-reversing agents in reactivating the HIV-1 reservoir in clinical studies: a systematic review
por: Debrabander, Quinten, et al.
Publicado: (2023)

Hypothetical questionnaires may overestimate willingness to participate in HIV cure research: Comparison of a cross-sectional survey to actual willingness to participate in an HIV cure study in the Netherlands
por: Prins, Henrieke A.B., et al.
Publicado: (2020)

The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy
por: Prins, Henrieke A. B., et al.
Publicado: (2023)

HIV transmission among acutely infected participants of a Dutch cohort study 2015–2021 is not associated with large, clustered outbreaks
por: Prins, Henrieke A.B., et al.
Publicado: (2023)

Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1
por: Palstra, Robert-Jan, et al.
Publicado: (2018)

Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents
por: Ne, Enrico, et al.
Publicado: (2022)

Towards the next step: LoViRet patients for HIV-1 cure studies
por: Crespo, Raquel, et al.
Publicado: (2020)

DEAD-ly Affairs: The Roles of DEAD-Box Proteins on HIV-1 Viral RNA Metabolism
por: Rao, Shringar, et al.
Publicado: (2022)

Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency
por: Stoszko, Mateusz, et al.
Publicado: (2020)

HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency
por: Crespo, Raquel, et al.
Publicado: (2022)

Online networks facilitating multidisciplinary healthcare: a novel strategy to curb COVID-19
por: Prins, Henrieke, et al.
Publicado: (2022)

Predictors of virological failure in HIV‐1‐infected patients switching to dolutegravir maintenance monotherapy
por: Wijting, IEA, et al.
Publicado: (2018)

The efficacy, pharmacokinetics, safety and cardiovascular risks of switching nevirapine to rilpivirine in HIV-1 patients: the RPV switch study
por: Rokx, Casper, et al.
Publicado: (2014)

Partner Notification for Reduction of HIV-1 Transmission and Related Costs among Men Who Have Sex with Men: A Mathematical Modeling Study
por: Nichols, Brooke E., et al.
Publicado: (2015)

More virological failure with lamivudine than emtricitabine in efavirenz and nevirapine regimens in the Dutch nationwide HIV Cohort
por: Rokx, Casper, et al.
Publicado: (2014)

Targeted HCV core antigen monitoring among HIV-positive men who have sex with men is cost-saving
por: Popping, Stephanie, et al.
Publicado: (2019)

Perceptions of HIV cure and willingness to participate in HIV cure-related trials among people enrolled in the Netherlands cohort study on acute HIV infection
por: van Paassen, Pien, et al.
Publicado: (2022)

Inducible HIV-1 Reservoir Quantification: Clinical Relevance, Applications and Advancements of TILDA
por: Lungu, Cynthia, et al.
Publicado: (2021)

HIV-1 resistance against dolutegravir fluctuates rapidly alongside erratic treatment adherence: a case report
por: van Kampen, Jeroen J.A., et al.
Publicado: (2022)

Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
por: Tromp, Katja, et al.
Publicado: (2021)

The BAF complex and HIV latency
por: Mahmoudi, Tokameh
Publicado: (2012)

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma
por: De Crignis, Elisa, et al.
Publicado: (2021)

HIV Eradication: Combinatorial Approaches to Activate Latent Viruses
por: De Crignis, Elisa, et al.
Publicado: (2014)

Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci
por: Rother, Magdalena B., et al.
Publicado: (2016)

Launching a multidisciplinary European collaboration towards a cure for HIV: The EU2Cure Consortium
por: Rokx, C., et al.
Publicado: (2021)

Statutory health insurance-covered pre-exposure prophylaxis in Germany: changing trends in nationwide tenofovir disoproxil/emtricitabine prescriptions during the COVID-19 pandemic
por: Prins, Henrieke, et al.
Publicado: (2023)

DDX3X and DDX3Y are redundant in protein synthesis
por: Venkataramanan, Srivats, et al.
Publicado: (2021)

Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly
por: Yang, Fenghua, et al.
Publicado: (2023)

Intention of physicians to implement guidelines for screening and treatment of latent tuberculosis infection in HIV-infected patients in The Netherlands: a mixed-method design
por: Evenblij, Kirsten, et al.
Publicado: (2016)

DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
por: Xu, Kun, et al.
Publicado: (2022)

A TLR6 polymorphism is associated with increased risk of Legionnaires’ Disease
por: Misch, Elizabeth Ann, et al.
Publicado: (2013)

Role of DDX3 in the pathogenesis of inflammatory bowel disease
por: Tantravedi, Saritha, et al.
Publicado: (2017)

Cytoplasmic DDX3 as prognosticator in male breast cancer
por: van der Pol, Carmen C., et al.
Publicado: (2021)

The prognostic effect of DDX3 upregulation in distant breast cancer metastases
por: Heerma van Voss, Marise R., et al.
Publicado: (2016)

Corrigendum: DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
por: Xu, Kun, et al.
Publicado: (2023)

DDX41-associated susceptibility to myeloid neoplasms
por: Makishima, Hideki, et al.
Publicado: (2023)

Characteristics and short- and long-term direct medical costs among adults with timely and delayed presentation for HIV care in the Netherlands
por: Popping, Stephanie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_db7qjq2eulnlldv6tblo6gdb96