A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

CpG Island promoter genes make up more than half of human genes, and a subset regulated by Polycomb-Repressive Complex 2 (PRC2(+)-CGI) become DNA hypermethylated and silenced in cancer. Here, we perform a systematic analysis of CGI genes across TCGA cancer types, finding that PRC2(+)-CGI genes are f...

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Detalles Bibliográficos
Autores principales: Zheng, Yueyuan, Huang, Guowei, Silva, Tiago C., Yang, Qian, Jiang, Yan-Yi, Koeffler, H. Phillip, Lin, De-Chen, Berman, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087678/
https://www.ncbi.nlm.nih.gov/pubmed/33931649
http://dx.doi.org/10.1038/s41467-021-22720-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087678/
https://www.ncbi.nlm.nih.gov/pubmed/33931649
http://dx.doi.org/10.1038/s41467-021-22720-0

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