Four single-basepair mutations in the ptx promoter of Bordetella bronchiseptica are sufficient to activate the expression of pertussis toxin

Secretion of pertussis toxin (PT) is the preeminent virulence trait of the human pathogen Bordetella pertussis, causing whooping cough. Bordetella bronchiseptica, although it harbors an intact 12-kb ptx–ptl operon, does not express PT due to an inactive ptx promoter (Pptx), which contains 18 SNPs (s...

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Detalles Bibliográficos
Autores principales: Chen, Qing, Gray, Mary C., Hewlett, Erik, Stibitz, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087692/
https://www.ncbi.nlm.nih.gov/pubmed/33931696
http://dx.doi.org/10.1038/s41598-021-88852-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087692/
https://www.ncbi.nlm.nih.gov/pubmed/33931696
http://dx.doi.org/10.1038/s41598-021-88852-x

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