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Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?

To sustain their malignancy, tumour cells acquire several metabolic adaptations such as increased oxygen, glucose, glutamine, and lipids uptake. Other metabolic processes are also enhanced as part of tumour metabolic reprogramming, for example, increased serine metabolism. Serine is a non-essential...

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Detalles Bibliográficos
Autores principales: McNamee, Megan Jessica, Michod, David, Niklison-Chirou, Maria Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087698/
https://www.ncbi.nlm.nih.gov/pubmed/33931592
http://dx.doi.org/10.1038/s41420-021-00474-4