GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

Increasing evidence supports that ferroptosis plays an important role in tumor growth inhibition. Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, has been shown to induce ferroptosis in hepatocellular carcinoma (HCC). However, some hepatoma cell lines are less sensiti...

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Detalles Bibliográficos
Autores principales: Wang, Qiujie, Bin, Cheng, Xue, Qiang, Gao, Qingzhu, Huang, Ailong, Wang, Kai, Tang, Ni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087704/
https://www.ncbi.nlm.nih.gov/pubmed/33931597
http://dx.doi.org/10.1038/s41419-021-03718-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087704/
https://www.ncbi.nlm.nih.gov/pubmed/33931597
http://dx.doi.org/10.1038/s41419-021-03718-4

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