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Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex
Serine proteases catalyze a multi-step covalent catalytic mechanism of peptide bond cleavage. It has long been assumed that serine proteases including thrombin carry-out catalysis without significant conformational rearrangement of their stable two-β-barrel structure. We present nuclear magnetic res...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087772/ https://www.ncbi.nlm.nih.gov/pubmed/33931701 http://dx.doi.org/10.1038/s41598-021-88432-z |