Cargando…

4‐phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR‐α

BACKGROUND AND AIMS: 4‐phenylbutyric acid (4‐PBA) is a low molecular weight fatty acid that is used in clinical practice to treat inherited urea cycle disorders. In previous reports, it acted as a chemical chaperone inhibiting endoplasmic reticulum (ER) stress and unfolded protein response signaling...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Shu‐Zhen, Ling, Yan, Yu, Le‐Xing, Song, Yu‐Ting, Chen, Xiao‐Fei, Cao, Qi‐Qi, Yu, Han, Chen, Can, Tang, Jiao‐Jiao, Fan, Zhe‐Cai, Miao, Yu‐Shan, Dong, Ya‐Ping, Tao, Jun‐Yan, Monga, Satdarshan P.S., Wen, Wen, Wang, Hong‐Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087947/ https://www.ncbi.nlm.nih.gov/pubmed/33931972 http://dx.doi.org/10.1002/ctm2.379

Ejemplares similares

BCL9/BCL9L in hepatocellular carcinoma: Will it or Wnt it be the next therapeutic target?
por: Moghe, Akshata, et al.
Publicado: (2020)

β-Catenin Activation in Hepatocellular Cancer: Implications in Biology and Therapy
por: Krutsenko, Yekaterina, et al.
Publicado: (2021)

4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis
por: Hong, Yu-pu, et al.
Publicado: (2016)

circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling
por: Guo, Xing-Ya, et al.
Publicado: (2018)

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice
por: Qiao, Yu, et al.
Publicado: (2018)

Corrigendum to “4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis”
por: Hong, Yu-pu, et al.
Publicado: (2018)

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
por: Feng, Jiao, et al.
Publicado: (2020)

A Novel Transgenic Mouse Model Implicates Sirt2 as a Promoter of Hepatocellular Carcinoma
por: Schmidt, Alexandra V., et al.
Publicado: (2023)

Chronic Activation of LXRα Sensitizes Mice to Hepatocellular Carcinoma
por: Xie, Yang, et al.
Publicado: (2022)

Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes
por: Xing, Dongyang, et al.
Publicado: (2022)

Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro
por: Liu, Shing-Hwa, et al.
Publicado: (2016)

Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
por: Chen, Xi-Yao, et al.
Publicado: (2021)

Sodium phenylbutyrate antagonizes prostate cancer through the induction of apoptosis and attenuation of cell viability and migration
por: Xu, Yawen, et al.
Publicado: (2016)

Clinical and Experimental Applications of Sodium Phenylbutyrate
por: Iannitti, Tommaso, et al.
Publicado: (2012)

Identification of enzymes involved in oxidation of phenylbutyrate
por: Palir, Neža, et al.
Publicado: (2017)

NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease
por: Li, Yaru, et al.
Publicado: (2020)

Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury
por: Gabdulkhakova, Adelya, et al.
Publicado: (2023)

Correction to: Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes
por: Xing, Dongyang, et al.
Publicado: (2023)

Efficacy of Azatyrosine-Phenylbutyric Hydroxamides, a Histone Deacetylase Inhibitor, on Chemotherapy-Induced Gastrointestinal Mucositis
por: Liao, Po-Lin, et al.
Publicado: (2019)

β-Catenin Loss in Hepatocytes Promotes Hepatocellular Cancer after Diethylnitrosamine and Phenobarbital Administration to Mice
por: Awuah, Prince Kwaku, et al.
Publicado: (2012)

Metabolomics of the interaction between PPAR-α and age in the PPAR-α-null mouse
por: Atherton, Helen J, et al.
Publicado: (2009)

4-Phenylbutyric acid improves free fatty acid-induced hepatic insulin resistance in vivo
por: Pereira, Sandra, et al.
Publicado: (2021)

Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination
por: Yadav, Anjali, et al.
Publicado: (2021)

Phenylbutyrate increases activity of pyruvate dehydrogenase complex
por: Ferriero, Rosa, et al.
Publicado: (2013)

Effects and mechanisms of PPARα activator fenofibrate on myocardial remodelling in hypertension
por: Li, Chuan-Bao, et al.
Publicado: (2009)

Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis
por: XiaoTian, Lei, et al.
Publicado: (2016)

HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCS/JAK2/STAT/PPAR-γ Signalling Pathway
por: Zhao, Min, et al.
Publicado: (2019)

Ductular Reaction and Liver Regeneration: Fulfilling the Prophecy of Prometheus!
por: Monga, Satdarshan P., et al.
Publicado: (2022)

CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway
por: Wang, Gang, et al.
Publicado: (2021)

Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways
por: Ji, Jie, et al.
Publicado: (2021)

4-Phenylbutyrate Prevents Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Heatstroke in the Intestines of Mice
por: Cao, Yan, et al.
Publicado: (2020)

Pretreatment with Sodium Phenylbutyrate Alleviates Cerebral Ischemia/Reperfusion Injury by Upregulating DJ-1 Protein
por: Yang, Rui-Xin, et al.
Publicado: (2017)

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway
por: He, Jinbiao, et al.
Publicado: (2022)

The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα
por: Wu, Qing-Qing, et al.
Publicado: (2019)

Association of serum zinc-α2-glycoprotein with non-alcoholic fatty liver disease
por: Qi, Xiao-Yan, et al.
Publicado: (2020)

4-Phenylbutyric Acid Induces Protection against Pulmonary Arterial Hypertension in Rats
por: Wu, Yun, et al.
Publicado: (2016)

Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation
por: Zhang, Jie, et al.
Publicado: (2021)

R-α-Lipoic Acid and 4-Phenylbutyric Acid Have Distinct Hypolipidemic Mechanisms in Hepatic Cells
por: He, Bo, et al.
Publicado: (2020)

Overexpression of Platelet-Derived Growth Factor Receptor Α D842V Mutants Prevents Liver Regeneration and Chemically Induced Hepatocarcinogenesis via Inhibition of MET and EGFR
por: Du, Zhao-Qing, et al.
Publicado: (2020)

4-PHENYLBUTYRATE: MOLECULAR MECHANISMS AND AGING INTERVENTION POTENTIAL
por: Bene, Michael R, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b0tagl908r2e54ipeptgafjol7