MR-Clust: clustering of genetic variants in Mendelian randomization with similar causal estimates

MOTIVATION: Mendelian randomization is an epidemiological technique that uses genetic variants as instrumental variables to estimate the causal effect of a risk factor on an outcome. We consider a scenario in which causal estimates based on each variant in turn differ more strongly than expected by...

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Detalles Bibliográficos
Autores principales: Foley, Christopher N, Mason, Amy M, Kirk, Paul D W, Burgess, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088327/
https://www.ncbi.nlm.nih.gov/pubmed/32915962
http://dx.doi.org/10.1093/bioinformatics/btaa778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088327/
https://www.ncbi.nlm.nih.gov/pubmed/32915962
http://dx.doi.org/10.1093/bioinformatics/btaa778

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