Cargando…

Periodontitis‐compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA‐378a promote local angiogenesis by targeting Sufu to activate the Hedgehog/Gli1 signalling

OBJECTIVES: Previously, our investigations demonstrated robust pro‐angiogenic potentials of extracellular vesicles secreted by periodontitis‐compromised dental pulp stem cells (P‐EVs) when compared to those from healthy DPSCs (H‐EVs), but the underlying mechanism remains unknown. MATERIALS AND METHO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Huan, Li, Xuan, Wu, Rui‐Xin, He, Xiao‐Tao, An, Ying, Xu, Xin‐Yue, Sun, Hai‐Hua, Wu, Li‐An, Chen, Fa‐Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088471/ https://www.ncbi.nlm.nih.gov/pubmed/33759282 http://dx.doi.org/10.1111/cpr.13026

Ejemplares similares

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation
por: Cherry, Amy L., et al.
Publicado: (2013)

A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response
por: Oh, Sekyung, et al.
Publicado: (2015)

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
por: Tukachinsky, Hanna, et al.
Publicado: (2010)

Antagonistic and Cooperative Actions of Kif7 and Sufu Define Graded Intracellular Gli Activities in Hedgehog Signaling
por: Law, Kelvin King Lo, et al.
Publicado: (2012)

Nek2A/SuFu feedback loop regulates Gli-mediated Hedgehog signaling pathway
por: Zhou, Fen, et al.
Publicado: (2016)

Exosomes from miRNA-378-modified adipose-derived stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by enhancing angiogenesis and osteogenesis via targeting miR-378 negatively regulated suppressor of fused (Sufu)
por: Nan, Kai, et al.
Publicado: (2021)

Regulator of cullins-1 (ROC1) negatively regulates the Gli2 regulator SUFU to activate the hedgehog pathway in bladder cancer
por: Wang, W., et al.
Publicado: (2021)

The proangiogenic effects of extracellular vesicles secreted by dental pulp stem cells derived from periodontally compromised teeth
por: Zhou, Huan, et al.
Publicado: (2020)

Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1–SUFU Interaction in PDA Cells
por: Wang, Xinshuo, et al.
Publicado: (2017)

Correction: The proangiogenic effects of extracellular vesicles secreted by dental pulp stem cells derived from periodontally compromised teeth
por: Zhou, Huan, et al.
Publicado: (2022)

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
por: Bardwell, A Jane, et al.
Publicado: (2022)

Stathmin inhibits proliferation and differentiation of dental pulp stem cells via sonic hedgehog/Gli
por: Ma, Dandan, et al.
Publicado: (2018)

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development
por: Raducu, Madalina, et al.
Publicado: (2016)

T396I Mutation of Mouse Sufu Reduces the Stability and Activity of Gli3 Repressor
por: Makino, Shigeru, et al.
Publicado: (2015)

Dual activation of Hedgehog and Wnt/β-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer
por: Peng, Yin, et al.
Publicado: (2021)

Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation
por: Qin, Tianli, et al.
Publicado: (2022)

Disrupting Hedgehog signaling in melanocytes by SUFU knockout leads to ocular melanocytosis and anterior segment malformation
por: Wang, Weizhuo, et al.
Publicado: (2023)

Gli inhibitor pricked by Hedgehog
por: Short, Ben
Publicado: (2010)

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling
por: Lin, Chuwen, et al.
Publicado: (2014)

Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth
por: Yan, Zhengwei, et al.
Publicado: (2021)

Extracellular Vesicles for Dental Pulp and Periodontal Regeneration
por: Lai, Hongbin, et al.
Publicado: (2023)

Gli2, hedgehog and TCR signalling
por: Furmanski, Anna L., et al.
Publicado: (2015)

Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth
por: Pan, Y B, et al.
Publicado: (2015)

BCC or not: Sufu keeps it in check
por: Yin, Wen-Chi, et al.
Publicado: (2015)

Developmental pathways: Sonic hedgehog-Patched-GLI.
por: Walterhouse, D O, et al.
Publicado: (1999)

Hedgehog Signaling and Truncated GLI1 in Cancer
por: Doheny, Daniel, et al.
Publicado: (2020)

Gli Phosphorylation Code in Hedgehog Signal Transduction
por: Zhou, Mengmeng, et al.
Publicado: (2022)

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
por: Infante, Paola, et al.
Publicado: (2018)

Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
por: Yung, Theodora, et al.
Publicado: (2019)

Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1
por: Götschel, Frank, et al.
Publicado: (2013)

Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis
por: Chen, Wenbiao, et al.
Publicado: (2022)

Comparative analysis of the microbial community and nutritional quality of sufu
por: Li, Xingjiang, et al.
Publicado: (2021)

MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2
por: Xu, Xinxin, et al.
Publicado: (2022)

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
por: Stecca, Barbara, et al.
Publicado: (2002)

Hedgehog and Gli Signaling in Embryonic Mammary Gland Development
por: Lee, May Yin, et al.
Publicado: (2013)

Sonic Hedgehog factor Gli1: As good as resistant
por: Zahreddine, Hiba Ahmad, et al.
Publicado: (2015)

Hedgehog-GLI mediated control of renal formation and malformation
por: Greenberg, Dina, et al.
Publicado: (2023)

Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
por: Florczyk-Soluch, Urszula, et al.
Publicado: (2023)

MicroRNA-378 is involved in hedgehog-driven epithelial-to-mesenchymal transition in hepatocytes of regenerating liver
por: Kim, Jieun, et al.
Publicado: (2018)

The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
por: Krist, Bart, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_q4bi9hvdaqg3pu2ihdbg3u4avh