The PKM2 activator TEPP‐46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF‐1α accumulation

AIMS/INTRODUCTION: Tubulointerstitial fibrosis is a hallmark of diabetic nephropathy and is associated with an epithelial‐to‐mesenchymal transition (EMT) program and aberrant glycolysis. Dimeric pyruvate kinase (PK) M2 (PKM2) acts as a key protein kinase in aberrant glycolysis by promoting the accum...

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Detalles Bibliográficos
Autores principales: Liu, Haijie, Takagaki, Yuta, Kumagai, Asako, Kanasaki, Keizo, Koya, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089020/
https://www.ncbi.nlm.nih.gov/pubmed/33314682
http://dx.doi.org/10.1111/jdi.13478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089020/
https://www.ncbi.nlm.nih.gov/pubmed/33314682
http://dx.doi.org/10.1111/jdi.13478

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