Global Wnt Inhibition With a Porcupine Inhibitor Decreases Established Trabecular Bone in a Mouse Model of Fibrous Dysplasia

Background: G protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions, including bone development and remodeling. Fibrous dysplasia (FD) is a common skeletal dysplasia caused by increased G(s)-GPCR signaling and characterized by fibrotic expansile bone lesions. FD has no...

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Detalles Bibliográficos
Autores principales: Lung, Hsuan, Moody, Tania, Wentworth, Kelly, Kang, Misun, Ho, Sunita, Hsiao, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Bone and Mineral Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089136/
http://dx.doi.org/10.1210/jendso/bvab048.475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089136/
http://dx.doi.org/10.1210/jendso/bvab048.475

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