LUBAC Suppresses IL-21-Induced Apoptosis in CD40-Activated Murine B Cells and Promotes Germinal Center B Cell Survival and the T-Dependent Antibody Response

B cell activation by Tfh cells, i.e., through CD154 engagement of CD40 and IL-21, and survival within GCs are crucial for the T-dependent Ab response. LUBAC, composed of HOIP, SHARPIN, and HOIL-1, catalyzes linear ubiquitination (Linear M1-Ub) to mediate NF-κB activation and cell survival induced by...

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Detalles Bibliográficos
Autores principales: Wang, Jingwei, Li, Tianbao, Zan, Hong, Rivera, Carlos E., Yan, Hui, Xu, Zhenming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089397/
https://www.ncbi.nlm.nih.gov/pubmed/33953720
http://dx.doi.org/10.3389/fimmu.2021.658048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089397/
https://www.ncbi.nlm.nih.gov/pubmed/33953720
http://dx.doi.org/10.3389/fimmu.2021.658048

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