Cargando…

LUBAC Suppresses IL-21-Induced Apoptosis in CD40-Activated Murine B Cells and Promotes Germinal Center B Cell Survival and the T-Dependent Antibody Response

B cell activation by Tfh cells, i.e., through CD154 engagement of CD40 and IL-21, and survival within GCs are crucial for the T-dependent Ab response. LUBAC, composed of HOIP, SHARPIN, and HOIL-1, catalyzes linear ubiquitination (Linear M1-Ub) to mediate NF-κB activation and cell survival induced by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jingwei, Li, Tianbao, Zan, Hong, Rivera, Carlos E., Yan, Hui, Xu, Zhenming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089397/ https://www.ncbi.nlm.nih.gov/pubmed/33953720 http://dx.doi.org/10.3389/fimmu.2021.658048

Ejemplares similares

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
por: Elliott, Paul R., et al.
Publicado: (2016)

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism
por: Zotos, Dimitra, et al.
Publicado: (2010)

Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway
por: Oikawa, Daisuke, et al.
Publicado: (2020)

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
por: Linterman, Michelle A., et al.
Publicado: (2010)

LUBAC: A new function in immunity
por: Boisson, Bertrand, et al.
Publicado: (2014)

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
por: Peltzer, Nieves, et al.
Publicado: (2018)

LUBAC determines chemotherapy resistance in squamous cell lung cancer
por: Ruiz, E. Josue, et al.
Publicado: (2019)

Henri de Lubac : la obra orgánica de una vida
por: Balthasar, Hans Urs von, 1905-1988
Publicado: (1989)

IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation
por: Dvorscek, Alexandra R, et al.
Publicado: (2022)

LUBAC and ABIN-1 Modulate TRAIL-Based NF-κB Induction in Human Embryonic Kidney 293 Cells
por: Dorn, Sebastian, et al.
Publicado: (2018)

Molecular Basis and Regulation of OTULIN-LUBAC Interaction
por: Elliott, Paul R., et al.
Publicado: (2014)

IL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B Cells
por: Franke, Fridolin, et al.
Publicado: (2020)

Quick and easy purification of murine untouched naive B cells or germinal center B cells by MACS
por: Ramezani-Rad, Parham, et al.
Publicado: (2021)

Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes
Publicado: (1996)

Human Non-Germinal Center B Cell Interleukin (IL)-12 Production Is Primarily Regulated by T Cell Signals CD40 Ligand, Interferon γ, and IL-10: Role of B Cells in the Maintenance of T Cell Responses
por: Schultze, Joachim L., et al.
Publicado: (1999)

Reciprocal interplay between OTULIN–LUBAC determines genotoxic and inflammatory NF-κB signal responses
por: Li, Mingqi, et al.
Publicado: (2022)

IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation
por: Petersone, Lina, et al.
Publicado: (2023)

Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development
por: Moribe, Fumiya, et al.
Publicado: (2021)

Tracking Murine Gammaherpesvirus 68 Infection of Germinal Center B Cells In Vivo
por: Collins, Christopher M., et al.
Publicado: (2012)

EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
por: Li, Yingqian, et al.
Publicado: (2016)

LUBAC: a new player in polyglucosan body disease
por: Aboujaoude, Andrew, et al.
Publicado: (2021)

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus
por: Wu, Zhixiao, et al.
Publicado: (2022)

Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction
Publicado: (1994)

Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division
por: Binder, Sebastian C., et al.
Publicado: (2016)

Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy
por: Miyashita, Hirohisa, et al.
Publicado: (2021)

Ripk1 and haematopoiesis: a case for LUBAC and Ripk3
por: Annibaldi, Alessandro, et al.
Publicado: (2018)

Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM(+) B cells
por: Abos, Beatriz, et al.
Publicado: (2020)

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory
Publicado: (1994)

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
por: Batten, Marcel, et al.
Publicado: (2010)

CD154-CD40 interactions in the control of murine B cell hematopoiesis
por: Carlring, Jennifer, et al.
Publicado: (2011)

Fam40b is required for lineage commitment of murine embryonic stem cells
por: Wagh, V, et al.
Publicado: (2014)

A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells
por: Lorenzo, Daniela, et al.
Publicado: (2016)

IL-21–induced Bɛ cell apoptosis mediated by natural killer T cells suppresses IgE responses
por: Harada, Michishige, et al.
Publicado: (2006)

CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype
Publicado: (1996)

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling
por: Klein, Theo, et al.
Publicado: (2015)

Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity
por: Khan, Mohsin, et al.
Publicado: (2016)

Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells
por: Ke, Fang, et al.
Publicado: (2023)

Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis
por: Hennino, Ana, et al.
Publicado: (2001)

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
por: Stieglitz, Benjamin, et al.
Publicado: (2012)

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia
por: Boisson, Bertrand, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_acqtsiqa1f4ck6bk3e6836pqfl