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LBD Dimerization of the Androgen Receptor but Not N/C Interaction Is Crucial for Normal Male Development in Mice

The androgen receptor (AR) is a nuclear receptor with a main role in the development and maintenance of the male phenotype. To execute its role as transcription factor, the AR forms homodimers. Three dimerization modes have been described for the AR: one via the DNA binding domain, a second via the...

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Detalles Bibliográficos
Autores principales: El Kharraz, Sarah, Helsen, Christine, Dubois, Vanessa, Libert, Claude, Poutanen, Matti, Claessens, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089729/
http://dx.doi.org/10.1210/jendso/bvab048.1675